A vast number of chemical reactions in our bodies are carried out by specialized proteins that function as microscopic, yet highly intricate molecular machines. Understanding how they work requires knowledge of what they look like at the molecular level, how they move, and how these motions enable their function.
Dr. Sebastian Deindl, Department of Chemistry and Chemical Biology, Harvard University, will study the workings of these protein machines at the molecular level. He will take advantage of single-molecule fluorescence microscopy techniques that he used at Harvard University, from where he will transfer. These state-of-the-art imaging techniques will allow him to study individual enzyme molecules at work, in particular those that interact with or alter our genetic information. Visualizing their movements in real-time will help unravel how they work at the molecular level.
Many human disease states involve the aberrant activity of important protein machines, and understanding their molecular mechanisms can be an important first step towards developing therapeutic intervention strategies. As a Wallenberg Academy Fellow, Sebastian Deindl will conduct his research at Uppsala University.
Photo: Manfred Deindl